IGF-1(insulin-like growth factor) is an endocrine hormone produced in the liver, and production of IGF-1 increases in the presence of growth hormone.There are many different types of cells in the body that have receptors for IGF-1.This makes IGF-1 a good actor in more autocrine cell signaling that targets tissues to promote cell-to-cell communication (growth) or to promote cell division.
IGF-1(insulin-like growth factor) is a growth factor closely related to insulin.It carries the same amount of amino acids as insulin and is responsible for the anabolic response to GH.IGF-1 is an important factor in childhood growth and is highly anabolic in adults.It is also known by the brand name Increlex and by the generic name Mecasermin.
The background of IGF - 1
In the 1970s, IGF-1 was referred to as the "Sulfation Factor" and the Nonsuppressible insulin-like Activity (NSILA).
In the 1980s, it was called "Somatomedin C." The most popular type of IGF-1 on the underground market is a more persistent version (longer length of amino acids) called long R3 insulin-like growth factor -I or long R3IGF-I.LR3IGF-1 is more effective than the smaller amino acid versions no longer available on the underground market. In this type of IGF, there are usually two types (Media and Receptor grades respectively), the last two types of IGF mainly refer to the purity of the actual amount in the bottle.
How IGF-1 works
IGF-1 is released in the liver and binds to intracellular IGF receptors, ultimately leading to stimulation of cell growth (both causing new tissue formation and growth of existing tissue) and inhibition of cell death.
It is a highly anabolic and anti-catabolic compound.For bodybuilders, this has a number of positive effects: increased nitrogen retention and protein synthesis due to its high level of anabolism.
IGF-1(in the presence of enough protein) promotes the growth of new muscle cells, which increases the total number of cells in the muscle.IGF also protects neurons in the brain and promotes the growth of new motor neurons, allowing them to learn new skills more quickly during use.
IGF-1 is also responsible for connective tissue production, improving collagen formation and contributing to cartilage repair.Also, it affects bone by helping it build and repair.
The advantages of IGF - 1
Helps regulate fat as energy, resulting in fat loss.
Helps fight aging.As we age, IGF-1 production slows down, leading to cell decline.Low levels of IGF-1 are associated with heart failure, lower brain cell regulation and neuronal function.Not to mention the breakdown of muscle tissue.
Helps increase nutrient shuttling (protein synthesis).Increase the regeneration function of nerve tissue.
Improves the ability of muscle cells to proliferate, resulting in fuller muscle tissue.
Two different types of IGF-1:
There are two types of IGF-1 variants: IGF-1 LR3 and DES IGF-1(commonly known as IGF-1 DES).The normal base IGF-1 has a very short half-life (about 10-20 minutes) and will be quickly metabolized by the body after use.This is why IGF-1 is modified to produce the amino acid analogue IGF-1 LR3.
IGF-1 LR3: IGF-1 LR3 has a half-life of about 20-30 hours and is more effective than basic IGF-1.With a half-life of about a day, IGF-1 LR3 will circulate in the body for about 24 hours, binding to receptors and activating cell communication, resulting in improved muscle growth and fat loss.
IGF-1 LR3 prevents glucose from entering cells, forcing the body to burn fat instead of sucrose.In addition, because of the long half-life of IGF-1 LR3, site-specific injection is not mandatory, because IGF-1 LR3 binds the body to all muscle cells for about a day.
IGF-1 DES: DES IGF-1 is a shorter version of IGF-1.It is five times stronger than IGF-LR3 and 10 times stronger than the conventional base IGF-1.IGF-1 DES has a half-life of about 20 to 30 minutes, so it can only be injected in specific areas where you want muscle to grow.DES has the ability to stimulate muscle proliferation better than LR3.Simply put, it is best used for point growth, not aggregate growth.In addition, IGF-1 DES is known to bind to receptors that deform lactic acid during training, which is usually present during muscle training, allowing IGF-1 DES to attach itself to the mutated receptor and signal tissue growth during training.IGF-1 DES can be used longer and more frequently than IGF-1 LR3.
IGF 1 and HGH
HGH growth hormone is actually a precursor to IGF-1.Growth hormone does not cause muscle growth directly, but indirectly by releasing IGF-1.Growth hormone (HGH) is usually very expensive, and it needs to be used in conjunction with insulin or other anabolic steroids if it is to cause significant muscle growth.
The use of IGF
IGF-1 LR3: IGF-1 LR3 can be used continuously 7 days a week at a dose of 50-150 MCG per day.Desensitization occurs in about 40 days or about 4 weeks.The injection site can be in any muscle group of the body, because it does not require a mandatory point-point injection.
IGF-1 DES: IGF-1 DES can be administered multiple times per day (pre-training) at doses of 50-150 MCG to specific target areas.Due to the short half-life nature of DES (20-30 minutes), desensitization was not noticed at all.The injection site should be localized.The injection is given to the part of the muscle that you want to promote growth.Simply put, if you want an extra boost to your biceps, inject IGF-1 DES into your biceps.
Side effects of IGF-1
High doses of IGF-1 cause hypoglycemia, but not nearly as much as insulin does.It has also been noted and highly debated that IGF-1 has been shown to increase tumor size in cancer patients, but IGF-1 is not a cause of cancer;In fact, our bodies need IGF-1 to regulate heart function, nervous system and brain cell stimulation.People with low IGF-1 levels are often protein deficient and are underweight and emasculated, which can be unhealthy.
IGF-1 related research data
In studies of young adult mice, compounds responsible for increasing IGF-1 secretion in muscle fibers were given.Muscle mass increased by an average of 15% and strength increased by 14%.When the adult mice were studied, the strength of the injected muscles increased by 27 percent compared with the uninjected muscles.It has also been found to prevent muscle aging.Muscle mass and muscle fiber growth are similar to those seen in young adults.These effects are likely due to IGF-1's ability to activate satellite cells and thus stimulate muscle regeneration.
In studies where GH and IGF1 were used together, an increase in lean body mass and fat loss was found compared with each compound used alone (2).Testosterone use is also thought to increase IGF levels in muscles.During the 12-week study using IGF-1, IGF-1+ GH or GH subjects alone in this study, approximately 3kgs of lean body mass was gained and approximately 2kgs of fat was lost.Intact human IGF-1 long R3 IGF-1 is 2-3 times more potent than IGF-1 because of the lower activity of the IGF-binding protein.