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Tetrapeptide-30 powder

Appearance White powder
Identification Positive
Assay 98.0% min
Single Impurity (HPLC) 0.5%max

Introduction

Tetrapeptide-30 is a new peptide developed to balance skin tone. There are various mechanisms to brighten skin tone, including reducing or inhibiting tyrosinase activity, blocking melanin transfer into keratinocytes, and inhibition of melanocyte activation. It is theorized that Tetrapeptide-30 Solution works by reducing the amount of tyrosinase and inhibiting melanocyte activation.


Item

Specification

Appearance

White powder

Identification

Positive

Assay

98.0% min

Single Impurity (HPLC) 

0.5%max

Amino Acid Composition 

±10% of theoretical

Peptide Content (N%)

 80.0%min.

Water Content(Karl Fischer) 

6.0%max.

Acetate Content (HPIC)

15.0%max.

Mass Balance 

95.0~105.0%


Function:

These tetrapeptides inhibit ultraviolet light (UV)-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) by

skin epithelial cells and fibroblasts. Furthermore, the tetrapeptides repress the upregulation of matrix metalloproteinase-1

(MMP-1) by skin fibroblasts induced by either direct exposure to UV rays or treatment with media conditioned by UV-treated keratinocytes. The small size and bio-activity of the tetrapeptides render them suitable for use in therapies directed to inflammatory skin disorders and as active ingredients in skin care products. 


Application:

1. Visibly diminishes hyperchromatic spots.

2. Improves evenness of skin tone.

3. Reduces lesions and melasma on ethnic skin.

4. Active on all kinds of skin types.

5. Provides significant anti-inflammatory effect.

6. Skin-friendly.

7. Safely inhibits the pigmentation process.

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