Home / Cosmetics Raw Material / Pentapeptide-18/Leuphasyl


CAS No.  64963-01-5
MF C29H39N5O7
Appearance Powder
Purity  > 99.0%


Pentapeptide-18 reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes. It targets in vitro the wrinkle-formation mechanism of expression wrinkles in a new way, offering an alternative to peptides like Acetyl Hexapeptide-3. It can be incorporated in cosmetic formulations such as emulsions, gels, and waxes 



CAS No.:







 > 99.0%

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 Within 1-3 days payment

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Pentapeptide-18 has been used in anti-wrinkle eye serum to reduce the the appearance of fine lines and wrinkles-crow's feet with significant improvement in skin roughness. It may work synergistically with Argirilene and increase the benefits notablely.

1.Improve microcirculation of the blood,

2.Strengthen blood circulation,

3.Eliminate inflammation,

4.Resist pouch and dilute the fine lines and cow’s feet around eyes

5.Delay the effects of premature aging by improving the elasticity and firmness of the skin.

6.Hydrate, protect and smooth skin


Pentapeptide-18 is a modified enkephalin that binds to extracellular and enkephalin receptors and releases the G protein group (a, β, v). Thus, the calcium channel is closed, the vesicles are unable to fuse, and the release of acetylcholine is blocked and the neurons are in a non-excited state. Therefore, muscle contraction is weakened to prevent the formation of fine lines and wrinkles.

It has anti-wrinkle effect and makes skin smooth and moist.

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