Myostatin GDF-8

CAS 901758-09-6
Appearance White powder
Purity 99%min
Application Increase muscle/body building

Introduction

Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo. Description : 28 kDa protein containing 243 amino acid residues of the Myostatin Propeptide and 5 additional amino acid residues. Myostatin (also known as differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell and differentiation. In humans it is encoded by the MSTN gene. Myostatin is differentiation factor that is a member of the TGF protein family. Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both of the myostatin gene have significantly more muscle mass. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.


Product Profile

Name

GDF-8

Synonyms

Myostatin GDF-8

CAS

901758-09-6

Appearance

White powder

Origin

China

Application

increase muscle/body building

Purity

99%min

Package`

1MG/vial;10 vials/kit(carton box)/ bulk wholesale in bag/drum package



Function

Myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation


Appliction

Myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.




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